Research ArticleSIGNAL TRANSDUCTION

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

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Science Advances  18 Sep 2015:
Vol. 1, no. 8, e1500221
DOI: 10.1126/sciadv.1500221

Article Information

vol. 1 no. 8

Online ISSN: 
History: 
  • Received for publication February 23, 2015
  • Accepted for publication June 30, 2015
  • .

Author Information

  1. Alexa S. Green1,2,3,4,*,
  2. Thiago T. Maciel5,6,7,8,*,
  3. Marie-Anne Hospital1,2,3,*,
  4. Chae Yin9,
  5. Fetta Mazed1,2,3,
  6. Elizabeth C. Townsend10,
  7. Sylvain Pilorge1,2,3,11,
  8. Mireille Lambert1,2,3,
  9. Etienne Paubelle5,6,7,8,
  10. Arnaud Jacquel11,
  11. Florence Zylbersztejn5,6,7,8,
  12. Justine Decroocq5,6,7,8,
  13. Laury Poulain1,2,3,
  14. Pierre Sujobert1,2,3,
  15. Nathalie Jacque1,2,3,
  16. Kevin Adam1,2,3,
  17. Jason C. C. So9,
  18. Olivier Kosmider1,2,3,
  19. Patrick Auberger11,
  20. Olivier Hermine5,6,7,8,
  21. David M. Weinstock10,
  22. Catherine Lacombe1,2,3,
  23. Patrick Mayeux1,2,3,
  24. Gary J. Vanasse12,
  25. Anskar Y. Leung9,
  26. Ivan C. Moura5,6,7,8,,
  27. Didier Bouscary1,2,3, and
  28. Jerome Tamburini1,2,3,,
  1. 1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
  2. 2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
  3. 3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
  4. 4Department of Hematology, Charles Nicolle University Hospital, Rouen 76000, France.
  5. 5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
  6. 6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
  7. 7CNRS ERL 8254, Paris 75015, France.
  8. 8Laboratory of Excellence GR-Ex, Paris 75015 , France.
  9. 9Division of Hematology, Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  10. 10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston 02115, MA 02115, USA.
  11. 11INSERM U1065/C3M Team 2, Cell Death Differentiation Inflammation and Cancer, Nice 06204, France.
  12. 12Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  1. Corresponding author. E-mail: jerome.tamburini{at}inserm.fr
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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