Research ArticleSIGNAL TRANSDUCTION
Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
- Alexa S. Green1,2,3,4,*,
- Thiago T. Maciel5,6,7,8,*,
- Marie-Anne Hospital1,2,3,*,
- Chae Yin9,
- View ORCID ProfileFetta Mazed1,2,3,
- View ORCID ProfileElizabeth C. Townsend10,
- Sylvain Pilorge1,2,3,11,
- Mireille Lambert1,2,3,
- Etienne Paubelle5,6,7,8,
- Arnaud Jacquel11,
- Florence Zylbersztejn5,6,7,8,
- Justine Decroocq5,6,7,8,
- Laury Poulain1,2,3,
- Pierre Sujobert1,2,3,
- Nathalie Jacque1,2,3,
- Kevin Adam1,2,3,
- Jason C. C. So9,
- Olivier Kosmider1,2,3,
- Patrick Auberger11,
- Olivier Hermine5,6,7,8,
- David M. Weinstock10,
- Catherine Lacombe1,2,3,
- Patrick Mayeux1,2,3,
- Gary J. Vanasse12,
- Anskar Y. Leung9,
- Ivan C. Moura5,6,7,8,†,
- Didier Bouscary1,2,3,† and
- Jerome Tamburini1,2,3,†,‡
- 1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
- 2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
- 3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
- 4Department of Hematology, Charles Nicolle University Hospital, Rouen 76000, France.
- 5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
- 6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
- 7CNRS ERL 8254, Paris 75015, France.
- 8Laboratory of Excellence GR-Ex, Paris 75015 , France.
- 9Division of Hematology, Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
- 10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston 02115, MA 02115, USA.
- 11INSERM U1065/C3M Team 2, Cell Death Differentiation Inflammation and Cancer, Nice 06204, France.
- 12Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
- ↵‡Corresponding author. E-mail: jerome.tamburini{at}inserm.fr
See allHide authors and affiliations
Science Advances 18 Sep 2015:
Vol. 1, no. 8, e1500221
DOI: 10.1126/sciadv.1500221
Vol. 1, no. 8, e1500221
DOI: 10.1126/sciadv.1500221
Alexa S. Green
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
4Department of Hematology, Charles Nicolle University Hospital, Rouen 76000, France.
Thiago T. Maciel
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
Marie-Anne Hospital
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Chae Yin
9Division of Hematology, Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fetta Mazed
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Elizabeth C. Townsend
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston 02115, MA 02115, USA.
Sylvain Pilorge
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
11INSERM U1065/C3M Team 2, Cell Death Differentiation Inflammation and Cancer, Nice 06204, France.
Mireille Lambert
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Etienne Paubelle
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
Arnaud Jacquel
11INSERM U1065/C3M Team 2, Cell Death Differentiation Inflammation and Cancer, Nice 06204, France.
Florence Zylbersztejn
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
Justine Decroocq
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
Laury Poulain
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Pierre Sujobert
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Nathalie Jacque
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Kevin Adam
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Jason C. C. So
9Division of Hematology, Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Olivier Kosmider
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Patrick Auberger
11INSERM U1065/C3M Team 2, Cell Death Differentiation Inflammation and Cancer, Nice 06204, France.
Olivier Hermine
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
David M. Weinstock
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston 02115, MA 02115, USA.
Catherine Lacombe
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Patrick Mayeux
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Gary J. Vanasse
12Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Anskar Y. Leung
9Division of Hematology, Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ivan C. Moura
5INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Paris 75015, France.
6Imagine Institute, Paris Descartes–Sorbonne Paris Cité University, Paris 75015, France.
7CNRS ERL 8254, Paris 75015, France.
8Laboratory of Excellence GR-Ex, Paris 75015 , France.
Didier Bouscary
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.
Jerome Tamburini
1Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France.
2Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France.
3Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.