Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

James Keaney; Dominic M. Walsh; Tiernan O’Malley; Natalie Hudson; Darragh E. Crosbie; Teresa Loftus; Florike Sheehan; Jacqueline McDaid; Marian M. Humphries; John J. Callanan; Francesca M. Brett; Michael A. Farrell; Peter Humphries; Matthew Campbell

doi:10.1126/sciadv.1500472

Research ArticleALZHEIMER’S DISEASE

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

James Keaney¹,
Dominic M. Walsh²,
Tiernan O’Malley²,
Natalie Hudson¹,
Darragh E. Crosbie¹,
Teresa Loftus³,
Florike Sheehan³,
Jacqueline McDaid¹,
Marian M. Humphries¹,
John J. Callanan⁴,⁵,
Francesca M. Brett³,
Michael A. Farrell³,
Peter Humphries¹ and
Matthew Campbell¹,*

¹Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
²Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
³Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
⁴UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
⁵Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.

↵*Corresponding author. E-mail: matthew.campbell{at}tcd.ie

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Science Advances 18 Sep 2015:
Vol. 1, no. 8, e1500472
DOI: 10.1126/sciadv.1500472

James Keaney

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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Dominic M. Walsh

Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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ORCID record for Dominic M. Walsh

Tiernan O’Malley

Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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Natalie Hudson

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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Darragh E. Crosbie

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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Teresa Loftus

Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.

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Florike Sheehan

Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.

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Jacqueline McDaid

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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Marian M. Humphries

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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John J. Callanan

UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.

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Francesca M. Brett

Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.

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Michael A. Farrell

Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.

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Peter Humphries

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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Matthew Campbell

Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.

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For correspondence: matthew.campbell@tcd.ie

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