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Research ArticleALZHEIMER’S DISEASE
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
- James Keaney1,
- View ORCID ProfileDominic M. Walsh2,
- View ORCID ProfileTiernan O’Malley2,
- Natalie Hudson1,
- Darragh E. Crosbie1,
- Teresa Loftus3,
- Florike Sheehan3,
- Jacqueline McDaid1,
- Marian M. Humphries1,
- John J. Callanan4,5,
- Francesca M. Brett3,
- Michael A. Farrell3,
- Peter Humphries1 and
- Matthew Campbell1,*
- 1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
- 2Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
- 3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
- 4UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
- 5Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.
- ↵*Corresponding author. E-mail: matthew.campbell{at}tcd.ie
See allHide authors and affiliations
Science Advances 18 Sep 2015:
Vol. 1, no. 8, e1500472
DOI: 10.1126/sciadv.1500472
Vol. 1, no. 8, e1500472
DOI: 10.1126/sciadv.1500472
James Keaney
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Dominic M. Walsh
2Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Tiernan O’Malley
2Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Natalie Hudson
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Darragh E. Crosbie
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Teresa Loftus
3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Florike Sheehan
3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Jacqueline McDaid
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Marian M. Humphries
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
John J. Callanan
4UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
5Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.
Francesca M. Brett
3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Michael A. Farrell
3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Peter Humphries
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Matthew Campbell
1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
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