Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

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Science Advances  23 Oct 2015:
Vol. 1, no. 9, e1500973
DOI: 10.1126/sciadv.1500973

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  • JAK- STAT dissection of hair follicle
    • Ranjeet Singh Mahla, Research scholar, Indian Institute of Science Education and Research, Bhopal, India

    The JAK-STAT signalling system consisted of cell surface cytokine receptor, Janus kinase (JAK) and signal transducer and activator (STAT), transmits immune signals from interferon, interleukins and other chemical massager to the promoter of target genes controlling growth, differentiation and cell death (1). Dysregulation of Immune signalling and androgenic alopecia can cause hair follicle miniaturization and alopecia aorta resulting to hair loss. Inhibition of JAK-STAT signalling is rarely shown to be explored for understanding the germinal potential of hair follicle (HF) stem cells. Harel et al. (2) investigated how JAK STAT signalling is involved in regulation of HF growth? Immunostaining and measurement of pigment intensity revealed that local inhibition of JAK- STAT by pharmacokinetic drugs tofacitinib and ruxolitinib results to rapid entry into hair cycle suggesting the role of JAK-STAT in regulation of quiescence stage of HF stem cells. JAK-STAT inhibition mimicking hair growth through Wnt and sonic hedgehog signalling can’t override the quiescence promoting micro environment during hair development but the same is effective in late telogen in mice with enhanced anagenic growth as revealed by pigment staining and activation of HF stem cells (2). Why we can’t use higher dose of pharmacokinetic inhibitor to break hair follicle stem cell’s quiescence at early telogen? Opposite to mice human have differential pattern of hair growth, where accurate measurement of HF’s a...

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    Competing Interests: None declared.

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