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Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

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Science Advances  12 Oct 2016:
Vol. 2, no. 10, e1600760
DOI: 10.1126/sciadv.1600760

Article Information

vol. 2 no. 10

Online ISSN: 
History: 
  • Received for publication April 9, 2016
  • Accepted for publication August 22, 2016

Author Information

  1. Sarah Picaud1,
  2. Katharina Leonards2,
  3. Jean-Philippe Lambert3,
  4. Oliver Dovey4,
  5. Christopher Wells1,
  6. Oleg Fedorov1,5,
  7. Octovia Monteiro1,5,
  8. Takao Fujisawa6,
  9. Chen-Yi Wang6,
  10. Hannah Lingard1,
  11. Cynthia Tallant1,5,
  12. Nikzad Nikbin7,
  13. Lucie Guetzoyan7,
  14. Richard Ingham7,
  15. Steven V. Ley7,
  16. Paul Brennan1,5,8,
  17. Susanne Muller1,5,
  18. Anastasia Samsonova9,
  19. Anne-Claude Gingras3,10,
  20. Juerg Schwaller2,
  21. George Vassiliou4,11,12,
  22. Stefan Knapp1,5,13,* and
  23. Panagis Filippakopoulos1,6,*
  1. 1Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, U.K.
  2. 2Laboratory of Childhood Leukemia, Department of Biomedicine, University of Basel and Basel University Children’s Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland.
  3. 3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  4. 4Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, U.K.
  5. 5Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, U.K.
  6. 6Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, U.K.
  7. 7Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  8. 8Alzheimer’s Research UK Oxford, Nuffield Department of Medicine Research Building, University of Oxford, Oxford OX3 7FZ, U.K.
  9. 9Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, U.K.
  10. 10Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  11. 11Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, U.K.
  12. 12Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, U.K.
  13. 13Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Goethe University, Max-von Laue Str. 9, 60438 Frankfurt am Main, Germany.
  1. *Corresponding author. Email: stefan.knapp{at}sgc.ox.ac.uk (S.K.); panagis.filippakopoulos{at}sgc.ox.ac.uk (P.F.)

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