An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

Johnny Habchi; Paolo Arosio; Michele Perni; Ana Rita Costa; Maho Yagi-Utsumi; Priyanka Joshi; Sean Chia; Samuel I. A. Cohen; Martin B. D. Müller; Sara Linse; Ellen A. A. Nollen; Christopher M. Dobson; Tuomas P. J. Knowles; Michele Vendruscolo

doi:10.1126/sciadv.1501244

Research ArticleNEUROSCIENCE

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

Johnny Habchi¹,
Paolo Arosio¹,
Michele Perni¹,
Ana Rita Costa¹,
Maho Yagi-Utsumi¹,
Priyanka Joshi¹,
Sean Chia¹,
Samuel I. A. Cohen¹,
Martin B. D. Müller²,
Sara Linse³,
Ellen A. A. Nollen²,
Christopher M. Dobson¹,*,
Tuomas P. J. Knowles¹,* and
Michele Vendruscolo¹,*

¹Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
²University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.
³Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, PO Box 124, 221 00 Lund, Sweden.

↵*Corresponding author. E-mail: mv245{at}cam.ac.uk (M.V.); tpjk2{at}cam.ac.uk (T.P.J.K.); cmd44{at}cam.ac.uk (C.M.D.)

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Science Advances 12 Feb 2016:
Vol. 2, no. 2, e1501244
DOI: 10.1126/sciadv.1501244

Johnny Habchi

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Paolo Arosio

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Michele Perni

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Ana Rita Costa

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Maho Yagi-Utsumi

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Priyanka Joshi

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Sean Chia

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Samuel I. A. Cohen

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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Martin B. D. Müller

University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.

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Sara Linse

Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, PO Box 124, 221 00 Lund, Sweden.

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ORCID record for Sara Linse

Ellen A. A. Nollen

University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.

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Christopher M. Dobson

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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For correspondence: mv245@cam.ac.uk tpjk2@cam.ac.uk cmd44@cam.ac.uk

Tuomas P. J. Knowles

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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For correspondence: mv245@cam.ac.uk tpjk2@cam.ac.uk cmd44@cam.ac.uk

Michele Vendruscolo

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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For correspondence: mv245@cam.ac.uk tpjk2@cam.ac.uk cmd44@cam.ac.uk

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An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

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