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Research ArticleNEUROSCIENCE
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
- Johnny Habchi1,
- Paolo Arosio1,
- Michele Perni1,
- Ana Rita Costa1,
- Maho Yagi-Utsumi1,
- View ORCID ProfilePriyanka Joshi1,
- Sean Chia1,
- Samuel I. A. Cohen1,
- Martin B. D. Müller2,
- View ORCID ProfileSara Linse3,
- Ellen A. A. Nollen2,
- Christopher M. Dobson1,*,
- Tuomas P. J. Knowles1,* and
- Michele Vendruscolo1,*
- 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
- 2University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.
- 3Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, PO Box 124, 221 00 Lund, Sweden.
- ↵*Corresponding author. E-mail: mv245{at}cam.ac.uk (M.V.); tpjk2{at}cam.ac.uk (T.P.J.K.); cmd44{at}cam.ac.uk (C.M.D.)
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Science Advances 12 Feb 2016:
Vol. 2, no. 2, e1501244
DOI: 10.1126/sciadv.1501244
Vol. 2, no. 2, e1501244
DOI: 10.1126/sciadv.1501244
Johnny Habchi
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Paolo Arosio
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Michele Perni
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Ana Rita Costa
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Maho Yagi-Utsumi
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Priyanka Joshi
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Sean Chia
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Samuel I. A. Cohen
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Martin B. D. Müller
2University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.
Sara Linse
3Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, PO Box 124, 221 00 Lund, Sweden.
Ellen A. A. Nollen
2University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.
Christopher M. Dobson
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Tuomas P. J. Knowles
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Michele Vendruscolo
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
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