Research ArticleCELL BIOLOGY

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

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Science Advances  25 Mar 2016:
Vol. 2, no. 3, e1501332
DOI: 10.1126/sciadv.1501332

Article Information

vol. 2 no. 3

Online ISSN: 
History: 
  • Received for publication September 25, 2015
  • Accepted for publication February 11, 2016
  • .

Author Information

  1. Sachiko Nishimoto1,*,
  2. Daiju Fukuda2,*,,
  3. Yasutomi Higashikuni3,
  4. Kimie Tanaka4,
  5. Yoichiro Hirata5,
  6. Chie Murata6,
  7. Joo-ri Kim-Kaneyama7,
  8. Fukiko Sato1,
  9. Masahiro Bando1,
  10. Shusuke Yagi2,
  11. Takeshi Soeki2,
  12. Tetsuya Hayashi8,
  13. Issei Imoto6,
  14. Hiroshi Sakaue1,
  15. Michio Shimabukuro9,10 and
  16. Masataka Sata2,
  1. 1Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  2. 2Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  3. 3Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
  4. 4Division for Health Service Promotion, The University of Tokyo, Tokyo 113-8655, Japan.
  5. 5Department of Pediatrics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
  6. 6Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  7. 7Department of Biochemistry, Showa University School of Medicine, Tokyo 142-8555, Japan.
  8. 8Laboratory of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka 569-1094, Japan.
  9. 9Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  10. 10Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital, Okinawa 901-0243, Japan.
  1. Corresponding author. E-mail: daiju.fukuda{at}tokushima-u.ac.jp (D.F.); masataka.sata{at}tokushima-u.ac.jp (M.S.)
    • * These authors contributed equally to this work.

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