Research ArticleMICROBIOLOGY
A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance
- View ORCID ProfileCameron A. McConkey1,*,
- View ORCID ProfileElizabeth Delorme-Axford1,†,
- Cheryl A. Nickerson2,
- Kwang Sik Kim3,
- Yoel Sadovsky1,4,
- Jon P. Boyle5 and
- Carolyn B. Coyne1,4,‡
- 1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 2The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA.
- 3Division of Infectious Diseases, The Johns Hopkins University, Baltimore, MD 21218, USA.
- 4Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA.
- 5Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
- ↵‡Corresponding author. E-mail: coynec2{at}pitt.edu
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Science Advances 04 Mar 2016:
Vol. 2, no. 3, e1501462
DOI: 10.1126/sciadv.1501462
Vol. 2, no. 3, e1501462
DOI: 10.1126/sciadv.1501462
Cameron A. McConkey
1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Elizabeth Delorme-Axford
1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Cheryl A. Nickerson
2The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA.
Kwang Sik Kim
3Division of Infectious Diseases, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yoel Sadovsky
1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.
4Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jon P. Boyle
5Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Carolyn B. Coyne
1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.
4Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA.
