Research ArticleCELL BIOLOGY

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1

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Science Advances  01 Apr 2016:
Vol. 2, no. 4, e1501290
DOI: 10.1126/sciadv.1501290

Article Information

vol. 2 no. 4

Online ISSN: 
History: 
  • Received for publication September 16, 2015
  • Accepted for publication February 25, 2016
  • .

Author Information

  1. Mohammad B. Hossain1,
  2. Rehnuma Shifat1,
  3. David G. Johnson2,
  4. Mark T. Bedford2,
  5. Konrad R. Gabrusiewicz1,
  6. Nahir Cortes-Santiago1,*,
  7. Xuemei Luo3,
  8. Zhimin Lu1,
  9. Ravesanker Ezhilarasan4,
  10. Erik P. Sulman4,
  11. Hong Jiang1,
  12. Shawn S. C. Li5,
  13. Frederick F. Lang6,
  14. Jessica Tyler2,,
  15. Mien-Chie Hung7,8,
  16. Juan Fueyo1,6, and
  17. Candelaria Gomez-Manzano1,9,
  1. 1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA.
  3. 3Biomolecular Resource Facility, The University of Texas Medical Branch, Galveston, TX 77555, USA.
  4. 4Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  5. 5Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
  6. 6Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  7. 7Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  8. 8Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan.
  9. 9Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. Corresponding author. E-mail: cmanzano{at}mdanderson.org (C.G.-M.); jfueyo{at}mdanderson.org (J.F.)
  • * Present address: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

  • Present address: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

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