Research ArticleMARINE POLLUTANTS

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

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Science Advances  15 Apr 2016:
Vol. 2, no. 4, e1600001
DOI: 10.1126/sciadv.1600001

Article Information

vol. 2 no. 4

Online ISSN: 
History: 
  • Received for publication January 1, 2016
  • Accepted for publication March 21, 2016
  • .

Author Information

  1. Sascha C. T. Nicklisch1,
  2. Steven D. Rees2,*,
  3. Aaron P. McGrath2,*,
  4. Tufan Gökirmak1,
  5. Lindsay T. Bonito1,
  6. Lydia M. Vermeer3,
  7. Cristina Cregger2,
  8. Greg Loewen3,
  9. Stuart Sandin1,
  10. Geoffrey Chang2,4 and
  11. Amro Hamdoun1,
  1. 1Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093–0202, USA.
  2. 2Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093–0657, USA.
  3. 3Sekisui XenoTech, LLC, 1101 West Cambridge Circle Drive, Kansas City, KS 66103, USA.
  4. 4Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093–0657, USA.
  1. Corresponding author. E-mail: hamdoun{at}ucsd.edu
    • * These authors contributed equally to this work.

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