Research ArticleBACTERIAL BIOFILMS

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

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Science Advances  20 May 2016:
Vol. 2, no. 5, e1501632
DOI: 10.1126/sciadv.1501632

Article Information

vol. 2 no. 5

Online ISSN: 
History: 
  • Received for publication November 12, 2015
  • Accepted for publication April 26, 2016
  • .

Author Information

  1. Perrin Baker1,
  2. Preston J. Hill2,
  3. Brendan D. Snarr3,4,
  4. Noor Alnabelseya1,5,
  5. Matthew J. Pestrak2,
  6. Mark J. Lee3,4,*,
  7. Laura K. Jennings6,
  8. John Tam1,
  9. Roman A. Melnyk1,5,
  10. Matthew R. Parsek6,
  11. Donald C. Sheppard3,4,
  12. Daniel J. Wozniak2 and
  13. P. Lynne Howell1,5,
  1. 1Program in Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  2. 2Departments of Microbial Infection and Immunity, Microbiology, Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA.
  3. 3Departments of Medicine, Microbiology, and Immunology, McGill University, Montréal, Québec H3A 2B4, Canada.
  4. 4Infectious Diseases and Immunity in Global Health Program, Centre for Translational Biology, McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
  5. 5Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  6. 6Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
  1. Corresponding author. Email: howell{at}sickkids.ca
  • * Present address: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90049, USA.

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