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Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

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Science Advances  27 May 2016:
Vol. 2, no. 5, e1600241
DOI: 10.1126/sciadv.1600241

Article Information

vol. 2 no. 5

Online ISSN: 
History: 
  • Received for publication February 5, 2016
  • Accepted for publication April 29, 2016
  • .

Author Information

  1. Chen Zhang1,*,
  2. Tuo Zhang2,*,
  3. Juan Zou1,*,
  4. Cassandra Lynn Miller1,*,
  5. Rakshya Gorkhali1,
  6. Jeong-Yeh Yang3,
  7. Anthony Schilmiller2,
  8. Shuo Wang3,
  9. Kenneth Huang1,
  10. Edward M. Brown4,
  11. Kelley W. Moremen3,
  12. Jian Hu2,5, and
  13. Jenny J. Yang1,
  1. 1Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 50 Decatur Street, Atlanta, GA 30303, USA.
  2. 2Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
  3. 3Department of Biochemistry and Molecular Biology and the Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.
  4. 4Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
  5. 5Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  1. Corresponding author. Email: jenny{at}gsu.edu (J.J.Y.); hujian1{at}msu.edu (J.H.)
    • * These authors contributed equally to this work.

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