Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

Anna King; Cornelia Ndifon; Sylvia Lui; Kate Widdows; Venkata R. Kotamraju; Lilach Agemy; Tambet Teesalu; Jocelyn D. Glazier; Francesco Cellesi; Nicola Tirelli; John D. Aplin; Erkki Ruoslahti; Lynda K. Harris

doi:10.1126/sciadv.1600349

Research ArticleHEALTH AND MEDICINE

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

Anna King¹,²,
Cornelia Ndifon¹,²,
Sylvia Lui¹,²,
Kate Widdows¹,²,
Venkata R. Kotamraju³,⁴,
Lilach Agemy³,⁴,*,
Tambet Teesalu³,⁴,†,
Jocelyn D. Glazier¹,²,
Francesco Cellesi⁵,‡,
Nicola Tirelli⁵,⁶,
John D. Aplin¹,²,
Erkki Ruoslahti³,⁴ and
Lynda K. Harris¹,²,⁵,§

¹Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.
²Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.
³Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
⁴Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.
⁵School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.
⁶Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

↵§Corresponding author. Email: lynda.k.harris{at}manchester.ac.uk

↵* Present address: Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Haifa, Israel.
↵† Present address: Laboratory of Cancer Biology, Institute of Biomedicine, Centre of Excellence for Translational Medicine, University of Tartu, Ravila 14b, 50411 Tartu, Estonia.
↵‡ Present address: Fondazione CEN-European Centre for Nanomedicine, Piazza Leonardo da Vinci 32, 20133 Milan, Italy; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Pace 9, I-20122 Milan, Italy; and Dipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta,” Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy.

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Science Advances 06 May 2016:
Vol. 2, no. 5, e1600349
DOI: 10.1126/sciadv.1600349

Anna King

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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Cornelia Ndifon

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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ORCID record for Cornelia Ndifon

Sylvia Lui

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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ORCID record for Sylvia Lui

Kate Widdows

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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Venkata R. Kotamraju

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

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Lilach Agemy

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

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Tambet Teesalu

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

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Jocelyn D. Glazier

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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Francesco Cellesi

School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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Nicola Tirelli

School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

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John D. Aplin

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

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Erkki Ruoslahti

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

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Lynda K. Harris

Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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For correspondence: lynda.k.harris@manchester.ac.uk

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