Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

Anna King; Cornelia Ndifon; Sylvia Lui; Kate Widdows; Venkata R. Kotamraju; Lilach Agemy; Tambet Teesalu; Jocelyn D. Glazier; Francesco Cellesi; Nicola Tirelli; John D. Aplin; Erkki Ruoslahti; Lynda K. Harris

doi:10.1126/sciadv.1600349

Research ArticleHEALTH AND MEDICINE

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

View ORCID ProfileAnna King¹,²,
View ORCID ProfileCornelia Ndifon¹,²,
View ORCID ProfileSylvia Lui¹,²,
Kate Widdows¹,²,
Venkata R. Kotamraju³,⁴,
Lilach Agemy³,⁴,*,
View ORCID ProfileTambet Teesalu³,⁴,†,
View ORCID ProfileJocelyn D. Glazier¹,²,
Francesco Cellesi⁵,‡,
Nicola Tirelli⁵,⁶,
View ORCID ProfileJohn D. Aplin¹,²,
Erkki Ruoslahti³,⁴ and
View ORCID ProfileLynda K. Harris¹,²,⁵,§

¹Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.
²Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.
³Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
⁴Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.
⁵School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.
⁶Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

↵§Corresponding author. Email: lynda.k.harris{at}manchester.ac.uk

↵* Present address: Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Haifa, Israel.
↵† Present address: Laboratory of Cancer Biology, Institute of Biomedicine, Centre of Excellence for Translational Medicine, University of Tartu, Ravila 14b, 50411 Tartu, Estonia.
↵‡ Present address: Fondazione CEN-European Centre for Nanomedicine, Piazza Leonardo da Vinci 32, 20133 Milan, Italy; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Pace 9, I-20122 Milan, Italy; and Dipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta,” Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy.

See allHide authors and affiliations

Science Advances 06 May 2016:
Vol. 2, no. 5, e1600349
DOI: 10.1126/sciadv.1600349

Anna King

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anna King

Cornelia Ndifon

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Cornelia Ndifon

Sylvia Lui

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sylvia Lui

Kate Widdows

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Venkata R. Kotamraju

3Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

4Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lilach Agemy

3Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

4Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tambet Teesalu

3Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

4Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tambet Teesalu

Jocelyn D. Glazier

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jocelyn D. Glazier

Francesco Cellesi

5School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicola Tirelli

5School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

6Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John D. Aplin

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for John D. Aplin

Erkki Ruoslahti

3Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

4Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lynda K. Harris

1Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

5School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lynda K. Harris
For correspondence: lynda.k.harris@manchester.ac.uk

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

Plain text

Vertical Tabs

Science Advances

Article Tools