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Research ArticleHEALTH AND MEDICINE
Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles
- Malgosia M. Pakulska1,2,*,
- View ORCID ProfileIrja Elliott Donaghue1,2,*,
- View ORCID ProfileJaclyn M. Obermeyer1,2,*,
- View ORCID ProfileAnup Tuladhar2,
- Christopher K. McLaughlin1,
- View ORCID ProfileTyler N. Shendruk3 and
- Molly S. Shoichet1,2,4,†
- 1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
- 2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
- 3The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3NP, UK.
- 4Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
- ↵†Corresponding author. Email: molly.shoichet{at}utoronto.ca
↵* These authors contributed equally to this work.
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Science Advances 27 May 2016:
Vol. 2, no. 5, e1600519
DOI: 10.1126/sciadv.1600519
Vol. 2, no. 5, e1600519
DOI: 10.1126/sciadv.1600519
Malgosia M. Pakulska
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
Irja Elliott Donaghue
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
Jaclyn M. Obermeyer
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
Anup Tuladhar
2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
Christopher K. McLaughlin
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
Tyler N. Shendruk
3The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3NP, UK.
Molly S. Shoichet
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
4Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
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