Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Malgosia M. Pakulska; Irja Elliott Donaghue; Jaclyn M. Obermeyer; Anup Tuladhar; Christopher K. McLaughlin; Tyler N. Shendruk; Molly S. Shoichet

doi:10.1126/sciadv.1600519

Research ArticleHEALTH AND MEDICINE

Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Malgosia M. Pakulska¹,²,*,
View ORCID ProfileIrja Elliott Donaghue¹,²,*,
View ORCID ProfileJaclyn M. Obermeyer¹,²,*,
View ORCID ProfileAnup Tuladhar²,
Christopher K. McLaughlin¹,
View ORCID ProfileTyler N. Shendruk³ and
Molly S. Shoichet¹,²,⁴,†

¹Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
²Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.
³The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3NP, UK.
⁴Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

↵†Corresponding author. Email: molly.shoichet{at}utoronto.ca

↵* These authors contributed equally to this work.

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Science Advances 27 May 2016:
Vol. 2, no. 5, e1600519
DOI: 10.1126/sciadv.1600519

Malgosia M. Pakulska

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.

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Irja Elliott Donaghue

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.

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ORCID record for Irja Elliott Donaghue

Jaclyn M. Obermeyer

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.

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Anup Tuladhar

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.

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Christopher K. McLaughlin

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.

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Tyler N. Shendruk

3The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3NP, UK.

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ORCID record for Tyler N. Shendruk

Molly S. Shoichet

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada.

4Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

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For correspondence: molly.shoichet@utoronto.ca

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Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

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