Research ArticleBIOMATERIALS
In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector
- Yi Li1,
- Marie Beitelshees1,
- Lei Fang1,
- Andrew Hill2,
- Mahmoud Kamal Ahmadi1,
- Mingfu Chen1,
- Bruce A. Davidson3,
- Paul Knight III3,4,
- Randall J. Smith Jr5,
- Stelios T. Andreadis1,5,6,
- Anders P. Hakansson4,7,
- Charles H. Jones1,2,* and
- Blaine A. Pfeifer1,2,*
- 1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
- 2Abcombi Biosciences Inc., Buffalo, NY 14260–4200, USA.
- 3Department of Anesthesiology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
- 4Department of Microbiology and Immunology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
- 5Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
- 6Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA.
- 7Division of Experimental Infection Medicine, Department of Laboratory Medicine, Lund University, Malmö SE-20502, Sweden.
- ↵*Corresponding author. Email: charles.jones{at}abcombibio.com (C.H.J.); blainepf{at}buffalo.edu (B.A.P.)
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Science Advances 01 Jul 2016:
Vol. 2, no. 7, e1600264
DOI: 10.1126/sciadv.1600264
Vol. 2, no. 7, e1600264
DOI: 10.1126/sciadv.1600264
Yi Li
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Marie Beitelshees
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Lei Fang
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Andrew Hill
2Abcombi Biosciences Inc., Buffalo, NY 14260–4200, USA.
Mahmoud Kamal Ahmadi
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Mingfu Chen
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Bruce A. Davidson
3Department of Anesthesiology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Paul Knight III
3Department of Anesthesiology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
4Department of Microbiology and Immunology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Randall J. Smith Jr
5Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
Stelios T. Andreadis
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
5Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
6Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA.
Anders P. Hakansson
4Department of Microbiology and Immunology, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
7Division of Experimental Infection Medicine, Department of Laboratory Medicine, Lund University, Malmö SE-20502, Sweden.
Charles H. Jones
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
2Abcombi Biosciences Inc., Buffalo, NY 14260–4200, USA.
Blaine A. Pfeifer
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260–4200, USA.
2Abcombi Biosciences Inc., Buffalo, NY 14260–4200, USA.
