Research ArticleMOLECULAR GENETICS

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

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Science Advances  05 Aug 2016:
Vol. 2, no. 8, e1600963
DOI: 10.1126/sciadv.1600963

Article Information

vol. 2 no. 8

Online ISSN: 
History: 
  • Received for publication May 2, 2016
  • Accepted for publication July 1, 2016
  • .

Author Information

  1. Inge Kühl1,
  2. Maria Miranda1,
  3. Viktor Posse2,
  4. Dusanka Milenkovic1,
  5. Arnaud Mourier1,3,
  6. Stefan J. Siira4,
  7. Nina A. Bonekamp1,
  8. Ulla Neumann5,
  9. Aleksandra Filipovska4,
  10. Paola Loguercio Polosa6,
  11. Claes M. Gustafsson2 and
  12. Nils-Göran Larsson1,7,*
  1. 1Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
  2. 2Department of Medical Biochemistry and Cell Biology, Göteborgs Universitet, 40530 Göteborg, Sweden.
  3. 3Université de Bordeaux and the Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires UMR 5095, Saint-Saëns, F-33077 Bordeaux, France.
  4. 4Harry Perkins Institute of Medical Research, Centre for Medical Research and School of Chemistry and Biochemistry, The University of Western Australia, Perth 6009, Australia.
  5. 5Central Microscopy, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.
  6. 6Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
  7. 7Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
  1. *Corresponding author. Email: larsson{at}age.mpg.de

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