Research ArticleGENE TRANSCRIPTION
The landscape of transcription errors in eukaryotic cells
- View ORCID ProfileJean-Francois Gout1,*,
- View ORCID ProfileWeiyi Li1,*,
- View ORCID ProfileClark Fritsch2,3,
- Annie Li2,
- Suraiya Haroon2,
- View ORCID ProfileLarry Singh2,
- View ORCID ProfileDing Hua4,
- Hossein Fazelinia4,
- Zach Smith5,
- View ORCID ProfileSteven Seeholzer4,
- View ORCID ProfileKelley Thomas6,
- Michael Lynch1,† and
- View ORCID ProfileMarc Vermulst2,†
- 1Department of Biology, Indiana University, Bloomington, IN 47405, USA.
- 2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
- 3Department of Cellular and Molecular Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 4Protein and Proteomics Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
- 5Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA.
- 6Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
- ↵†Corresponding author. Email: vermulstm{at}email.chop.edu (M.V.); milynch{at}indiana.edu (M.L.)
↵* These authors contributed equally to this work.
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Science Advances 20 Oct 2017:
Vol. 3, no. 10, e1701484
DOI: 10.1126/sciadv.1701484
Vol. 3, no. 10, e1701484
DOI: 10.1126/sciadv.1701484
Jean-Francois Gout
1Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Weiyi Li
1Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Clark Fritsch
2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
3Department of Cellular and Molecular Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Annie Li
2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Suraiya Haroon
2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Larry Singh
2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Ding Hua
4Protein and Proteomics Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Hossein Fazelinia
4Protein and Proteomics Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Zach Smith
5Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA.
Steven Seeholzer
4Protein and Proteomics Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.
Kelley Thomas
6Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Michael Lynch
1Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Marc Vermulst
2Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19102, USA.