Research ArticleANTIBIOTICS

Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation

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Science Advances  04 Oct 2017:
Vol. 3, no. 10, e1701776
DOI: 10.1126/sciadv.1701776

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  • RE: The focus on pollutants should be transformed--A concern of nano-pollution
    • Zhi Guo, Teacher of Environmental Science, School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, P.R. China

    In their Article “Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation” (Science Advances, 04 October, 2017, Vol. 3, no. 10, e1701776), Nagpal et al. highlight the combinatorial utility of engineered stimuli-responsive nanoparticles potentiate antibiotics activity of Escherichia coli, Salmonella enterica, and Klebsiella pneumonia. Antibiotic abuse has produced a great threat to the environment (1). A new kind of pollution is quietly emerging; which may evolve into a severe environmental problem with the occurrence and development of nanotechnology (2). We have paid too little attention to this new nano-pollution and nano-pollutants (such as carbon nanotubes, graphene, QDs, metal and metal oxide nanoparticles), for the reason that our whole concerns are located on the traditional pollutants. Importantly, nano-pollutants perform their damage more than individually and even potentiate the threat of existed pollutants. Following the development and use of nanotechnology, nano-pollution certainly will develop into one of the most serious environmental problems that we need to deal with:

    The first consideration is the distribution of these new pollutants around the world; this step is the foundation of its control. However, we need to build a systematic and rapid analysis method to detect the quantity of nano-pollutants before the investigation of distribution can be performed. As we all know, nano-pollutants is differe...

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    Competing Interests: None declared.

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