Research ArticleHEALTH AND MEDICINE

A null mutation in SERPINE1 protects against biological aging in humans

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Science Advances  15 Nov 2017:
Vol. 3, no. 11, eaao1617
DOI: 10.1126/sciadv.aao1617

Article Information

vol. 3 no. 11

Online ISSN: 
History: 
  • Received for publication June 26, 2017
  • Accepted for publication October 10, 2017
  • .

Author Information

  1. Sadiya S. Khan1,2,3,*,
  2. Sanjiv J. Shah1,2,*,
  3. Ekaterina Klyachko1,2,
  4. Abigail S. Baldridge3,
  5. Mesut Eren2,
  6. Aaron T. Place2,
  7. Abraham Aviv4,
  8. Eli Puterman5,
  9. Donald M. Lloyd-Jones1,3,
  10. Meadow Heiman6,
  11. Toshio Miyata7,
  12. Sweta Gupta6,
  13. Amy D. Shapiro6 and
  14. Douglas E. Vaughan1,2,
  1. 1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  2. 2Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  3. 3Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  4. 4Center for Human Development and Aging, New Jersey Medical School, Newark, NJ 07103, USA.
  5. 5School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.
  6. 6Indiana Hemophilia and Thrombosis Center, Indianapolis, IN 46260, USA.
  7. 7Tohoku University Graduate School of Medicine, Miyagi, Japan.
  1. Corresponding author. Email: d-vaughan{at}northwestern.edu
    • * These authors contributed equally to this work.

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