Research ArticleHEALTH AND MEDICINE
Synthetic “smart gel” provides glucose-responsive insulin delivery in diabetic mice
- View ORCID ProfileAkira Matsumoto1,*,†,
- Miyako Tanaka2,*,
- Hiroko Matsumoto1,
- Kozue Ochi2,
- Yuki Moro-oka1,
- Hirohito Kuwata2,3,
- Hironori Yamada1,
- Ibuki Shirakawa4,
- Taiki Miyazawa1,
- Hitoshi Ishii3,
- Kazunori Kataoka5,6,
- Yoshihiro Ogawa7,8,9,
- Yuji Miyahara1 and
- View ORCID ProfileTakayoshi Suganami2,†
- 1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
- 2Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
- 3Department of Diabetology, Nara Medical University, Nara, Japan.
- 4Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
- 5Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Japan.
- 6Policy Alternatives Research Institute, University of Tokyo, Tokyo, Japan.
- 7Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
- 8Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 9Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (CREST), Tokyo, Japan.
- ↵†Corresponding author. Email: matsumoto.bsr{at}tmd.ac.jp (A.M.); suganami{at}riem.nagoya-u.ac.jp (T.S.)
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Advances 22 Nov 2017:
Vol. 3, no. 11, eaaq0723
DOI: 10.1126/sciadv.aaq0723
Vol. 3, no. 11, eaaq0723
DOI: 10.1126/sciadv.aaq0723
Akira Matsumoto
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Miyako Tanaka
2Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Hiroko Matsumoto
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Kozue Ochi
2Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Yuki Moro-oka
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Hirohito Kuwata
2Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
3Department of Diabetology, Nara Medical University, Nara, Japan.
Hironori Yamada
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Ibuki Shirakawa
4Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Taiki Miyazawa
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Hitoshi Ishii
3Department of Diabetology, Nara Medical University, Nara, Japan.
Kazunori Kataoka
5Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Japan.
6Policy Alternatives Research Institute, University of Tokyo, Tokyo, Japan.
Yoshihiro Ogawa
7Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
8Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
9Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (CREST), Tokyo, Japan.
Yuji Miyahara
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Takayoshi Suganami
2Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
