Research ArticleBIOCHEMISTRY

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

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Science Advances  24 Mar 2017:
Vol. 3, no. 3, e1601692
DOI: 10.1126/sciadv.1601692

Article Information

vol. 3 no. 3

Online ISSN: 
History: 
  • Received for publication July 21, 2016
  • Accepted for publication February 9, 2017
  • .

Author Information

  1. Jesse Goyette1,*,
  2. Citlali Solis Salas2,
  3. Nicola Coker-Gordon1,
  4. Marcus Bridge1,
  5. Samuel A. Isaacson3,
  6. Jun Allard4 and
  7. Omer Dushek1,2,
  1. 1Sir William Dunn School of Pathology, University of Oxford, Oxford, U.K.
  2. 2Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, U.K.
  3. 3Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
  4. 4Department of Mathematics, University of California, Irvine, Irvine, CA 92697, USA.
  1. Corresponding author. Email: omer.dushek{at}path.ox.ac.uk
  • * Present address: Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

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