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A dynamic hydrophobic core orchestrates allostery in protein kinases

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Science Advances  07 Apr 2017:
Vol. 3, no. 4, e1600663
DOI: 10.1126/sciadv.1600663

Article Information

vol. 3 no. 4

Online ISSN: 
History: 
  • Received for publication March 28, 2016
  • Accepted for publication March 15, 2017

Author Information

  1. Jonggul Kim1,2,*,
  2. Lalima G. Ahuja3,
  3. Fa-An Chao2,,
  4. Youlin Xia2,
  5. Christopher L. McClendon3,4,,
  6. Alexandr P. Kornev3,
  7. Susan S. Taylor3,4 and
  8. Gianluigi Veglia1,2,§
  1. 1Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
  2. 2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
  3. 3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
  4. 4Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.
  1. §Corresponding author. Email: vegli001{at}umn.edu
  • * Present address: Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

  • Present address: Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

  • Present address: Medicine Design, Pfizer Inc. 1 Portland Street, Cambridge, MA 02139, USA.

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