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Research ArticleBIOCHEMISTRY
A dynamic hydrophobic core orchestrates allostery in protein kinases
- Jonggul Kim1,2,*,
- View ORCID ProfileLalima G. Ahuja3,
- View ORCID ProfileFa-An Chao2,†,
- View ORCID ProfileYoulin Xia2,
- View ORCID ProfileChristopher L. McClendon3,4,‡,
- View ORCID ProfileAlexandr P. Kornev3,
- Susan S. Taylor3,4 and
- Gianluigi Veglia1,2,§
- 1Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
- 2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
- 3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
- 4Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.
- ↵§Corresponding author. Email: vegli001{at}umn.edu
↵* Present address: Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
↵† Present address: Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
↵‡ Present address: Medicine Design, Pfizer Inc. 1 Portland Street, Cambridge, MA 02139, USA.
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Science Advances 07 Apr 2017:
Vol. 3, no. 4, e1600663
DOI: 10.1126/sciadv.1600663
Vol. 3, no. 4, e1600663
DOI: 10.1126/sciadv.1600663
Jonggul Kim
1Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Lalima G. Ahuja
3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Fa-An Chao
2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Youlin Xia
2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Christopher L. McClendon
3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
4Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.
Alexandr P. Kornev
3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Susan S. Taylor
3Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
4Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.
Gianluigi Veglia
1Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
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