Research ArticleGENETICS

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

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Science Advances  28 Apr 2017:
Vol. 3, no. 4, e1602506
DOI: 10.1126/sciadv.1602506

Article Information

vol. 3 no. 4

Online ISSN: 
History: 
  • Received for publication October 12, 2016
  • Accepted for publication March 2, 2017

Author Information

  1. Shih-Chieh Chiang1,
  2. Martin Meagher2,
  3. Nick Kassouf3,
  4. Majid Hafezparast4,
  5. Peter J. McKinnon5,
  6. Rachel Haywood3 and
  7. Sherif F. El-Khamisy1,6,*
  1. 1Krebs Institute and Sheffield Institute for Nucleic Acids, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, U.K.
  2. 2Wellcome Trust Centre for Mitochondrial Research, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  3. 3RAFT Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, U.K.
  4. 4School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K.
  5. 5Department of Genetics, St. Jude Children’s Research Hospital, Memphis, TN 38105–3678, USA.
  6. 6Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12588, Egypt.
  1. *Corresponding author. Email: s.el-khamisy{at}sheffield.ac.uk

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