Directional mechanical stability of Bacteriophage φ29 motor’s 3WJ-pRNA: Extraordinary robustness along portal axis

Zhonghe Xu; Yang Sun; Jeffrey K. Weber; Yi Cao; Wei Wang; Daniel Jasinski; Peixuan Guo; Ruhong Zhou; Jingyuan Li

doi:10.1126/sciadv.1601684

Research ArticleBIOPHYSICS

Directional mechanical stability of Bacteriophage φ29 motor’s 3WJ-pRNA: Extraordinary robustness along portal axis

View ORCID ProfileZhonghe Xu¹,²,*,
View ORCID ProfileYang Sun³,*,
Jeffrey K. Weber⁴,
View ORCID ProfileYi Cao³,
Wei Wang³,
Daniel Jasinski⁵,
View ORCID ProfilePeixuan Guo⁵,
View ORCID ProfileRuhong Zhou¹,⁴,⁶,† and
Jingyuan Li¹,²,†

¹Institute of Quantitative Biology and Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027, China.
²Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
³Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu 210093, China.
⁴IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.
⁵Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry; College of Medicine/Department of Physiology & Cell Biology; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
⁶Department of Chemistry, Columbia University, New York, NY 10027, USA.

↵†Corresponding author. Email: lijingyuan{at}ihep.ac.cn (J.L.); ruhongz{at}us.ibm.com (R.Z.)

↵* These authors contributed equally to this work.

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Science Advances 26 May 2017:
Vol. 3, no. 5, e1601684
DOI: 10.1126/sciadv.1601684

Zhonghe Xu

1Institute of Quantitative Biology and Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027, China.

2Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

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ORCID record for Zhonghe Xu

Yang Sun

3Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu 210093, China.

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Jeffrey K. Weber

4IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.

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Yi Cao

3Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu 210093, China.

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Wei Wang

3Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu 210093, China.

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Daniel Jasinski

5Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry; College of Medicine/Department of Physiology & Cell Biology; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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Peixuan Guo

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Ruhong Zhou

1Institute of Quantitative Biology and Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027, China.

4IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.

6Department of Chemistry, Columbia University, New York, NY 10027, USA.

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For correspondence: lijingyuan@ihep.ac.cn ruhongz@us.ibm.com

Jingyuan Li

1Institute of Quantitative Biology and Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027, China.

2Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

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For correspondence: lijingyuan@ihep.ac.cn ruhongz@us.ibm.com

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Directional mechanical stability of Bacteriophage φ29 motor’s 3WJ-pRNA: Extraordinary robustness along portal axis

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