Research ArticleSTRUCTURAL BIOLOGY
Structures of closed and open conformations of dimeric human ATM
- Domagoj Baretić1,*,
- Hannah K. Pollard2,
- David I. Fisher2,
- Christopher M. Johnson1,
- Balaji Santhanam1,
- Caroline M. Truman2,
- Tomas Kouba1,
- Alan R. Fersht1,
- Christopher Phillips2 and
- Roger L. Williams1,*
- 1Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
- 2Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.
- ↵*Corresponding author. Email: rlw{at}mrc-lmb.cam.ac.uk (R.L.W.); domi{at}mrc-lmb.cam.ac.uk (D.B.)
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Science Advances 10 May 2017:
Vol. 3, no. 5, e1700933
DOI: 10.1126/sciadv.1700933
Vol. 3, no. 5, e1700933
DOI: 10.1126/sciadv.1700933
Domagoj Baretić
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Hannah K. Pollard
Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.
David I. Fisher
Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.
Christopher M. Johnson
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Balaji Santhanam
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Caroline M. Truman
Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.
Tomas Kouba
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Alan R. Fersht
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Christopher Phillips
Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.
Roger L. Williams
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
