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A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex

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Science Advances  02 Jun 2017:
Vol. 3, no. 6, e1601217
DOI: 10.1126/sciadv.1601217

Article Information

vol. 3 no. 6

Online ISSN: 
History: 
  • Received for publication May 28, 2016
  • Accepted for publication April 7, 2017
  • .

Author Information

  1. Honglei Ma1,2,*,
  2. Jingbo Duan3,*,
  3. Jiyuan Ke2,*,,
  4. Yuanzheng He2,
  5. Xin Gu2,
  6. Ting-Hai Xu1,2,
  7. Hong Yu3,
  8. Yonghong Wang3,
  9. Joseph S. Brunzelle4,
  10. Yi Jiang1,
  11. Scott B. Rothbart5,
  12. H. Eric Xu1,2,,
  13. Jiayang Li3, and
  14. Karsten Melcher2,
  1. 1Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.
  2. 2Center of Cancer and Cell Biology, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.
  3. 3State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China.
  4. 4Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.
  5. 5Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  1. Corresponding author. Email: eric.xu{at}vai.org (H.E.X.); jyli{at}genetics.ac.cn (J.L.); karsten.melcher{at}vai.org (K.M.)
    • * These authors contributed equally to this work.

    • Present address: NewLink Genetics, 2503 South Loop Drive, Suite 5100, Ames, IA 50010, USA.

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