Research ArticleHEART DISEASE

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

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Science Advances  07 Jun 2017:
Vol. 3, no. 6, e1603081
DOI: 10.1126/sciadv.1603081

Article Information

vol. 3 no. 6

Online ISSN: 
History: 
  • Received for publication December 5, 2016
  • Accepted for publication April 17, 2017

Author Information

  1. Li-Yen R. Hu1,*,
  2. Maegen A. Ackermann1,*,,
  3. Peter A. Hecker2,,
  4. Benjamin L. Prosser3,4,
  5. Brendan King1,
  6. Kelly A. O’Connell2,§,
  7. Alyssa Grogan1,
  8. Logan C. Meyer5,
  9. Christopher E. Berndsen5,
  10. Nathan T. Wright5,
  11. W. Jonathan Lederer3 and
  12. Aikaterini Kontrogianni-Konstantopoulos1,
  1. 1Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
  2. 2Division of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
  3. 3Department of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  4. 4Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
  1. Corresponding author. Email: akontrogianni{at}som.umaryland.edu
    • * These authors contributed equally to this work.

    • Present address: Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.

    • Present address: Brigham Young University–J. Reuben Clark Law School, 341 East Campus Drive, Provo, UT 84602, USA.

    • § Present address: FUJIFILM VisualSonics, 3080 Yonge Street, Suite 6300, Toronto, Ontario M4N 3N1, Canada.

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