Research ArticleDEVELOPMENTAL GENETICS

Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory

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Science Advances  16 Aug 2017:
Vol. 3, no. 8, e1701143
DOI: 10.1126/sciadv.1701143

Article Information

vol. 3 no. 8

Online ISSN: 
History: 
  • Received for publication April 3, 2017
  • Accepted for publication July 21, 2017
  • .

Author Information

  1. Adam Klosin1,2,*,
  2. Kadri Reis1,2,*,
  3. Cristina Hidalgo-Carcedo1,2,
  4. Eduard Casas3,
  5. Tanya Vavouri3,4 and
  6. Ben Lehner1,2,5,
  1. 1European Molecular Biology Laboratory–Centre for Genomic Regulation (EMBL-CRG) Systems Biology Unit, CRG, the Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
  2. 2Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  3. 3Program of Predictive and Personalized Medicine of Cancer–Institute Germans Trias i Pujol, Can Ruti Campus, Ctra de Can Ruti, Camí de les Escoles s/n, Badalona, 08916 Barcelona, Spain.
  4. 4Josep Carreras Leukaemia Research Institute (IJC), Can Ruti Campus, Ctra de Can Ruti, Camí de les Escoles s/n, Badalona, 08916 Barcelona, Spain.
  5. 5Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain.
  1. Corresponding author. Email: ben.lehner{at}crg.eu
    • * Co-first authors.

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