Research ArticleGENOME SEQUENCING
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
- View ORCID ProfileYavuz S. Dagdas1,*,
- View ORCID ProfileJanice S. Chen2,*,
- View ORCID ProfileSamuel H. Sternberg3,†,
- View ORCID ProfileJennifer A. Doudna2,3,4,5,‡ and
- View ORCID ProfileAhmet Yildiz2,6,‡
- 1Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
- 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- 3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
- 4Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
- 5Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
- 6Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
- ↵‡Corresponding author. Email: yildiz{at}berkeley.edu (A.Y.); doudna{at}berkeley.edu (J.A.D.)
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Science Advances 04 Aug 2017:
Vol. 3, no. 8, eaao0027
DOI: 10.1126/sciadv.aao0027
Vol. 3, no. 8, eaao0027
DOI: 10.1126/sciadv.aao0027
Yavuz S. Dagdas
1Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
Janice S. Chen
2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Samuel H. Sternberg
3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Jennifer A. Doudna
2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
4Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
5Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ahmet Yildiz
2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
6Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
