Research ArticleGENOME SEQUENCING
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
- Yavuz S. Dagdas1,*,
- Janice S. Chen2,*,
- Samuel H. Sternberg3,†,
- Jennifer A. Doudna2,3,4,5,‡ and
- Ahmet Yildiz2,6,‡
- 1Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
- 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- 3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
- 4Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
- 5Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
- 6Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
- ↵‡Corresponding author. Email: yildiz{at}berkeley.edu (A.Y.); doudna{at}berkeley.edu (J.A.D.)
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Science Advances 04 Aug 2017:
Vol. 3, no. 8, eaao0027
DOI: 10.1126/sciadv.aao0027
Vol. 3, no. 8, eaao0027
DOI: 10.1126/sciadv.aao0027
Yavuz S. Dagdas
Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
Janice S. Chen
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Samuel H. Sternberg
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Jennifer A. Doudna
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ahmet Yildiz
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
