Research ArticleGENOME EDITING

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

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Science Advances  30 Aug 2017:
Vol. 3, no. 8, eaao4774
DOI: 10.1126/sciadv.aao4774

Article Information

vol. 3 no. 8

Online ISSN: 
  • Received for publication July 25, 2017
  • Accepted for publication August 4, 2017
  • .

Author Information

  1. Alexis C. Komor1,2,3,*,
  2. Kevin T. Zhao1,2,3,
  3. Michael S. Packer1,2,3,,
  4. Nicole M. Gaudelli1,2,3,
  5. Amanda L. Waterbury1,
  6. Luke W. Koblan1,2,3,
  7. Y. Bill Kim1,2,3,
  8. Ahmed H. Badran1,2,3 and
  9. David R. Liu1,2,3,
  1. 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  2. 2Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  3. 3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  1. Corresponding author. Email: drliu{at}
  • * Present address: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

  • Present address: Beam Therapeutics, Cambridge, MA 02142, USA.


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