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Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations

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Science Advances  07 Nov 2018:
Vol. 4, no. 11, eaau0731
DOI: 10.1126/sciadv.aau0731

Article Information

vol. 4 no. 11

Online ISSN: 
History: 
  • Received for publication May 3, 2018
  • Accepted for publication October 3, 2018
  • .

Author Information

  1. Jaesung P. Choi1,
  2. Rui Wang2,
  3. Xi Yang2,
  4. Xian Wang1,
  5. Lu Wang3,
  6. Ka Ka Ting4,
  7. Matthew Foley5,
  8. Victoria Cogger6,
  9. Zhuo Yang7,
  10. Feng Liu3,
  11. Zhiming Han3,
  12. Renjing Liu8,
  13. Jonathan Baell9 and
  14. Xiangjian Zheng1,2,*
  1. 1Laboratory of Cardiovascular Signaling, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
  2. 2Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
  3. 3Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  4. 4Centre for the Endothelium, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
  5. 5Australian Centre for Microscopy & Microanalysis, University of Sydney, Sydney, NSW 2006, Australia.
  6. 6ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia.
  7. 7Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  8. 8Agnes Ginges Laboratory for Diseases of the Aorta, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
  9. 9Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
  1. *Corresponding author. Email: x.zheng{at}sydney.edu.au

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