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Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma

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Science Advances  14 Nov 2018:
Vol. 4, no. 11, eaau4580
DOI: 10.1126/sciadv.aau4580

Article Information

vol. 4 no. 11

Online ISSN: 
History: 
  • Received for publication June 12, 2018
  • Accepted for publication October 12, 2018
  • .

Author Information

  1. Alexey V. Stepanov1,
  2. Oleg V. Markov2,
  3. Ivan V. Chernikov2,
  4. Daniil V. Gladkikh2,
  5. Hongkai Zhang3,4,
  6. Teresa Jones3,
  7. Alexandra V. Sen’kova2,
  8. Elena L. Chernolovskaya2,
  9. Marina A. Zenkova2,
  10. Roman S. Kalinin1,
  11. Maria P. Rubtsova5,
  12. Alexander N. Meleshko6,
  13. Dmitry D. Genkin7,
  14. Alexey A. Belogurov Jr.1,
  15. Jia Xie3,*,
  16. Alexander G. Gabibov1,* and
  17. Richard A. Lerner3,*
  1. 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow V-437, Russian Federation.
  2. 2Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 8, 630090 Novosibirsk, Russian Federation.
  3. 3Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road MB-10, La Jolla, CA 92037, USA.
  4. 4State Key Laboratory of Medicinal Chemical Biology, Nankai University, 38 Tongyan Road, Tianjin 300350, China.
  5. 5Chemistry Department, M.V. Lomonosov Moscow State University, Lenin Hills, 1, bld. 3, 119991 Moscow, Russian Federation.
  6. 6Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
  7. 7OJSC Pharmsynthez, 197110 St. Petersburg, Russian Federation.
  1. *Corresponding author. Email: jiaxie{at}scripps.edu (J.X.); gabibov{at}mx.ibch.ru (A.G.G.); rlerner{at}scripps.edu (R.A.L.)

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