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Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

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Science Advances  14 Nov 2018:
Vol. 4, no. 11, eaau9859
DOI: 10.1126/sciadv.aau9859

Article Information

vol. 4 no. 11

Online ISSN: 
History: 
  • Received for publication August 2, 2018
  • Accepted for publication October 15, 2018
  • .

Author Information

  1. Michael J. Castle1,*,
  2. Yuhsiang Cheng1,
  3. Aravind Asokan2,3,4, and
  4. Mark H. Tuszynski1,5,*
  1. 1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. 3Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  4. 4Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  5. 5Veterans Administration Medical Center, San Diego, CA 92161, USA.
  1. *Corresponding author. Email: mcastle{at}ucsd.edu (M.J.C.); mtuszynski{at}ucsd.edu (M.H.T.)
  • Present address: Department of Surgery, Department of Molecular Genetics and Microbiology, Duke University School of Medicine, 203 Research Drive, MSRB1, Durham, NC 27710, USA.

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