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A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

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Science Advances  28 Nov 2018:
Vol. 4, no. 11, eaav2623
DOI: 10.1126/sciadv.aav2623

Article Information

vol. 4 no. 11

Online ISSN: 
History: 
  • Received for publication August 30, 2018
  • Accepted for publication October 30, 2018
  • .

Author Information

  1. Evan M. Cornett1,
  2. Bradley M. Dickson1,
  3. Krzysztof Krajewski2,
  4. Nicholas Spellmon3,
  5. Andrew Umstead4,
  6. Robert M. Vaughan1,
  7. Kevin M. Shaw1,
  8. Philip P. Versluis1,
  9. Martis W. Cowles5,
  10. Joseph Brunzelle6,
  11. Zhe Yang3,
  12. Irving E. Vega4,
  13. Zu-Wen Sun5 and
  14. Scott B. Rothbart1,*
  1. 1Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  2. 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. 3Department of Microbiology, Immunology, and Biochemistry, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  4. 4Department of Translational Science and Molecular Medicine and Integrated Mass Spectrometry Unit, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
  5. 5EpiCypher Inc., Research Triangle Park, NC 27709, USA.
  6. 6Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.
  1. *Corresponding author. Email: scott.rothbart{at}vai.org

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