Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging

Yi Sun; Sixian You; Haohua Tu; Darold R. Spillman; Eric J. Chaney; Marina Marjanovic; Joanne Li; Ronit Barkalifa; Jianfeng Wang; Anna M. Higham; Natasha N. Luckey; Kimberly A. Cradock; Z. George Liu; Stephen A. Boppart

doi:10.1126/sciadv.aau5603

Research ArticleCANCER

Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging

View ORCID ProfileYi Sun¹,²,
Sixian You¹,³,
Haohua Tu¹,
Darold R. Spillman Jr.¹,
View ORCID ProfileEric J. Chaney¹,
Marina Marjanovic¹,³,
Joanne Li¹,³,
View ORCID ProfileRonit Barkalifa¹,
View ORCID ProfileJianfeng Wang¹,
Anna M. Higham⁴,
View ORCID ProfileNatasha N. Luckey⁴,
View ORCID ProfileKimberly A. Cradock⁴,
Z. George Liu⁴ and
View ORCID ProfileStephen A. Boppart ¹,²,³,⁴,⁵,⁶,*

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
²Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
³Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
⁴Carle Foundation Hospital, Urbana, IL 61801, USA.
⁵Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
⁶Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

↵*Corresponding author. Email: boppart{at}illinois.edu

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Science Advances 19 Dec 2018:
Vol. 4, no. 12, eaau5603
DOI: 10.1126/sciadv.aau5603

Yi Sun

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Sixian You

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Haohua Tu

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Darold R. Spillman Jr.

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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ORCID record for Darold R. Spillman Jr.

Eric J. Chaney

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Marina Marjanovic

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Joanne Li

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Ronit Barkalifa

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Jianfeng Wang

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Anna M. Higham

4Carle Foundation Hospital, Urbana, IL 61801, USA.

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Natasha N. Luckey

4Carle Foundation Hospital, Urbana, IL 61801, USA.

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Kimberly A. Cradock

4Carle Foundation Hospital, Urbana, IL 61801, USA.

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Z. George Liu

4Carle Foundation Hospital, Urbana, IL 61801, USA.

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Stephen A. Boppart

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

4Carle Foundation Hospital, Urbana, IL 61801, USA.

5Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

6Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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For correspondence: boppart@illinois.edu

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