Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging

Yi Sun; Sixian You; Haohua Tu; Darold R. Spillman; Eric J. Chaney; Marina Marjanovic; Joanne Li; Ronit Barkalifa; Jianfeng Wang; Anna M. Higham; Natasha N. Luckey; Kimberly A. Cradock; Z. George Liu; Stephen A. Boppart

doi:10.1126/sciadv.aau5603

Research ArticleCANCER

Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging

Yi Sun¹,²,
Sixian You¹,³,
Haohua Tu¹,
Darold R. Spillman Jr.¹,
Eric J. Chaney¹,
Marina Marjanovic¹,³,
Joanne Li¹,³,
Ronit Barkalifa¹,
Jianfeng Wang¹,
Anna M. Higham⁴,
Natasha N. Luckey⁴,
Kimberly A. Cradock⁴,
Z. George Liu⁴ and
Stephen A. Boppart ¹,²,³,⁴,⁵,⁶,*

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
²Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
³Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
⁴Carle Foundation Hospital, Urbana, IL 61801, USA.
⁵Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
⁶Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

↵*Corresponding author. Email: boppart{at}illinois.edu

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Science Advances 19 Dec 2018:
Vol. 4, no. 12, eaau5603
DOI: 10.1126/sciadv.aau5603

Yi Sun

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Sixian You

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Haohua Tu

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Darold R. Spillman

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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ORCID record for Darold R. Spillman

Eric J. Chaney

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Marina Marjanovic

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Joanne Li

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Ronit Barkalifa

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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ORCID record for Ronit Barkalifa

Jianfeng Wang

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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Anna M. Higham

Carle Foundation Hospital, Urbana, IL 61801, USA.

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Natasha N. Luckey

Carle Foundation Hospital, Urbana, IL 61801, USA.

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Kimberly A. Cradock

Carle Foundation Hospital, Urbana, IL 61801, USA.

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Z. George Liu

Carle Foundation Hospital, Urbana, IL 61801, USA.

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Stephen A. Boppart

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.Carle Foundation Hospital, Urbana, IL 61801, USA.Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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For correspondence: boppart@illinois.edu

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