Research ArticleDEVELOPMENTAL BIOLOGY

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

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Science Advances  21 Feb 2018:
Vol. 4, no. 2, eaao1261
DOI: 10.1126/sciadv.aao1261

Article Information

vol. 4 no. 2

Online ISSN: 
History: 
  • Received for publication June 19, 2017
  • Accepted for publication January 10, 2018
  • .

Author Information

  1. Mette Handberg-Thorsager1,*,,
  2. Juliana Gutierrez-Mazariegos2,,
  3. Stefan T. Arold3,
  4. Eswar Kumar Nadendla4,
  5. Paola Y. Bertucci1,
  6. Pierre Germain4,
  7. Pavel Tomançak5,
  8. Keely Pierzchalski6,
  9. Jace W. Jones6,
  10. Ricard Albalat7,
  11. Maureen A. Kane6,
  12. William Bourguet4,
  13. Vincent Laudet2,,§,,
  14. Detlev Arendt1,8,, and
  15. Michael Schubert9,,
  1. 1Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
  2. 2Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Institut National de la Recherche Agronomique, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.
  3. 3King Abdullah University of Science and Technology, Center for Computational Bioscience Research, Division of Biological and Environmental Sciences and Engineering, Thuwal 23955-6900, Saudi Arabia.
  4. 4Centre de Biochimie Structurale, Inserm, CNRS, Université de Montpellier, 29 Rue de Navacelles, 34090 Montpellier, France.
  5. 5Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
  6. 6Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.
  7. 7Departament de Genètica, Microbiologia i Estadística, Institut de Recerca de la Biodiversitat (IRBio), Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain.
  8. 8Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.
  9. 9Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-Mer, Observatoire Océanologique de Villefranche-sur-Mer, 181 Chemin du Lazaret, 06230 Villefranche-sur-Mer, France.
  1. Corresponding author. Email: michael.schubert{at}obs-vlfr.fr (M.S.); arendt{at}embl.de (D.A.); vincent.laudet{at}obs-banyuls.fr (V.L.)
    • * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

    • These authors contributed equally to this work.

    • These authors contributed equally to this work.

    • § Present address: Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, CNRS, Observatoire Océanologique de Banyuls-sur-Mer, Avenue Pierre Fabre, 66650 Banyuls-sur-Mer, France.

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