Research ArticleBIOCHEMISTRY
Autoregulation of von Willebrand factor function by a disulfide bond switch
- Diego Butera1,
- Freda Passam2,
- Lining Ju3,
- Kristina M. Cook1,
- Heng Woon1,
- Camilo Aponte-Santamaría4,5,*,
- Elizabeth Gardiner6,
- Amanda K. Davis7,
- Deirdre A. Murphy8,
- Agnieszka Bronowska4,
- Brenda M. Luken9,†,
- Carsten Baldauf10,
- Shaun Jackson3,
- Robert Andrews11,
- Frauke Gräter4 and
- Philip J. Hogg1,12,‡
- 1The Centenary Institute, Newtown, New South Wales, Australia.
- 2St George Clinical School, Kogarah, New South Wales, Australia.
- 3Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
- 4Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
- 5Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
- 6Department of Cancer Biology and Therapeutics, John Curtin School of Medicine, Australian National University, Canberra, Australia.
- 7Haematology Unit, Alfred Hospital, Melbourne, Victoria, Australia.
- 8Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia.
- 9Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 10Fritz Haber Institute, Faradayweg 4-6, Berlin-Dahlem, Germany.
- 11Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
- 12National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
- ↵‡Corresponding author. Email: phil.hogg{at}sydney.edu.au
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Science Advances 28 Feb 2018:
Vol. 4, no. 2, eaaq1477
DOI: 10.1126/sciadv.aaq1477
Vol. 4, no. 2, eaaq1477
DOI: 10.1126/sciadv.aaq1477
Diego Butera
The Centenary Institute, Newtown, New South Wales, Australia.
Freda Passam
St George Clinical School, Kogarah, New South Wales, Australia.
Lining Ju
Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Kristina M. Cook
The Centenary Institute, Newtown, New South Wales, Australia.
Heng Woon
The Centenary Institute, Newtown, New South Wales, Australia.
Camilo Aponte-Santamaría
Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
Elizabeth Gardiner
Department of Cancer Biology and Therapeutics, John Curtin School of Medicine, Australian National University, Canberra, Australia.
Amanda K. Davis
Haematology Unit, Alfred Hospital, Melbourne, Victoria, Australia.
Deirdre A. Murphy
Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia.
Agnieszka Bronowska
Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
Brenda M. Luken
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Carsten Baldauf
Fritz Haber Institute, Faradayweg 4-6, Berlin-Dahlem, Germany.
Shaun Jackson
Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Robert Andrews
Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Frauke Gräter
Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
Philip J. Hogg
The Centenary Institute, Newtown, New South Wales, Australia.
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
