Research ArticleBIOCHEMISTRY
Autoregulation of von Willebrand factor function by a disulfide bond switch
- View ORCID ProfileDiego Butera1,
- View ORCID ProfileFreda Passam2,
- View ORCID ProfileLining Ju3,
- View ORCID ProfileKristina M. Cook1,
- Heng Woon1,
- Camilo Aponte-Santamaría4,5,*,
- View ORCID ProfileElizabeth Gardiner6,
- View ORCID ProfileAmanda K. Davis7,
- View ORCID ProfileDeirdre A. Murphy8,
- View ORCID ProfileAgnieszka Bronowska4,
- View ORCID ProfileBrenda M. Luken9,†,
- View ORCID ProfileCarsten Baldauf10,
- View ORCID ProfileShaun Jackson3,
- Robert Andrews11,
- Frauke Gräter4 and
- View ORCID ProfilePhilip J. Hogg1,12,‡
- 1The Centenary Institute, Newtown, New South Wales, Australia.
- 2St George Clinical School, Kogarah, New South Wales, Australia.
- 3Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
- 4Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
- 5Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
- 6Department of Cancer Biology and Therapeutics, John Curtin School of Medicine, Australian National University, Canberra, Australia.
- 7Haematology Unit, Alfred Hospital, Melbourne, Victoria, Australia.
- 8Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia.
- 9Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 10Fritz Haber Institute, Faradayweg 4-6, Berlin-Dahlem, Germany.
- 11Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
- 12National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
- ↵‡Corresponding author. Email: phil.hogg{at}sydney.edu.au
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Science Advances 28 Feb 2018:
Vol. 4, no. 2, eaaq1477
DOI: 10.1126/sciadv.aaq1477
Vol. 4, no. 2, eaaq1477
DOI: 10.1126/sciadv.aaq1477
Diego Butera
1The Centenary Institute, Newtown, New South Wales, Australia.
Freda Passam
2St George Clinical School, Kogarah, New South Wales, Australia.
Lining Ju
3Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Kristina M. Cook
1The Centenary Institute, Newtown, New South Wales, Australia.
Heng Woon
1The Centenary Institute, Newtown, New South Wales, Australia.
Camilo Aponte-Santamaría
4Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
5Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
Elizabeth Gardiner
6Department of Cancer Biology and Therapeutics, John Curtin School of Medicine, Australian National University, Canberra, Australia.
Amanda K. Davis
7Haematology Unit, Alfred Hospital, Melbourne, Victoria, Australia.
Deirdre A. Murphy
8Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia.
Agnieszka Bronowska
4Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
Brenda M. Luken
9Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Carsten Baldauf
10Fritz Haber Institute, Faradayweg 4-6, Berlin-Dahlem, Germany.
Shaun Jackson
3Heart Research Institute and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Robert Andrews
11Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Frauke Gräter
4Heidelberg Institute for Theoretical Studies, Schloß-Wolfsbrunnenweg 35, Heidelberg, Germany.
Philip J. Hogg
1The Centenary Institute, Newtown, New South Wales, Australia.
12National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
