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Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation

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Science Advances  21 Mar 2018:
Vol. 4, no. 3, eaap8492
DOI: 10.1126/sciadv.aap8492

Article Information

vol. 4 no. 3

Online ISSN: 
History: 
  • Received for publication September 1, 2017
  • Accepted for publication February 12, 2018
  • .

Author Information

  1. Yikui Zhang1,2,*,
  2. Lian Zhao1,*,
  3. Xu Wang1,
  4. Wenxin Ma1,
  5. Adam Lazere1,
  6. Hao-hua Qian3,
  7. Jun Zhang4,
  8. Mones Abu-Asab5,
  9. Robert N. Fariss6,
  10. Jerome E. Roger7,8 and
  11. Wai T. Wong1,
  1. 1Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325027, China.
  3. 3Visual Function Core, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  5. 5Section on Histopathology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  6. 6Biological Imaging Core, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  7. 7Centre d’Etude et de Recherche Thérapeutique en Ophtalmologie (CERTO), Retina France, Orsay, France.
  8. 8Paris-Saclay Institute of Neuroscience, CNRS, Université Paris-Sud, Université Paris-Saclay, Orsay, France.
  1. Corresponding author. Email: wongw{at}nei.nih.gov
  • * These authors contributed equally to this work.

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