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Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

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Science Advances  07 Mar 2018:
Vol. 4, no. 3, eaar2631
DOI: 10.1126/sciadv.aar2631

Article Information

vol. 4 no. 3

Online ISSN: 
History: 
  • Received for publication October 19, 2017
  • Accepted for publication February 2, 2018
  • .

Author Information

  1. Hui Huang1,2,
  2. Georg Kuenze2,3,4,
  3. Jarrod A. Smith1,2,
  4. Keenan C. Taylor1,2,
  5. Amanda M. Duran2,3,4,
  6. Arina Hadziselimovic1,2,
  7. Jens Meiler2,3,4,5,
  8. Carlos G. Vanoye6,
  9. Alfred L. George Jr6 and
  10. Charles R. Sanders1,2,7,*
  1. 1Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA.
  2. 2Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.
  3. 3Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
  4. 4Department of Pharmacology, Vanderbilt University, Nashville, TN 37240, USA.
  5. 5Department of Bioinformatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  6. 6Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  7. 7Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  1. *Corresponding author. Email: chuck.sanders{at}vanderbilt.edu

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