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Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current

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Science Advances  11 Apr 2018:
Vol. 4, no. 4, eaaq1438
DOI: 10.1126/sciadv.aaq1438

Article Information

vol. 4 no. 4

Online ISSN: 
History: 
  • Received for publication October 5, 2017
  • Accepted for publication February 21, 2018
  • .

Author Information

  1. Fei Yang1,2,*,
  2. Michael Anderson1,*,
  3. Shaoqiu He1,
  4. Kimberly Stephens3,
  5. Yu Zheng4,
  6. Zhiyong Chen1,
  7. Srinivasa N. Raja1,
  8. Felix Aplin5,
  9. Yun Guan1,5, and
  10. Gene Fridman4,6,7,
  1. 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
  2. 2Department of Neurobiology, Capital Medical University, Beijing 100069, PR China.
  3. 3Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.
  4. 4Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
  5. 5Department of Neurological Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
  6. 6Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
  7. 7Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
  1. Corresponding author. Email: gfridma1{at}jhmi.edu (G.F.); yguan1{at}jhmi.edu (Y.G.)
    • * These authors contributed equally to this work.

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