Research ArticleHEALTH AND MEDICINE

A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

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Science Advances  04 Apr 2018:
Vol. 4, no. 4, eaas8667
DOI: 10.1126/sciadv.aas8667

Article Information

vol. 4 no. 4

Online ISSN: 
History: 
  • Received for publication December 27, 2017
  • Accepted for publication February 20, 2018
  • .

Author Information

  1. Prashasti Kumar1,
  2. Engin H. Serpersu1,2,3,* and
  3. Matthew J. Cuneo4,*
  1. 1University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA.
  2. 2National Science Foundation, 2415 Eisenhower Avenue, Alexandria, VA 22314, USA.
  3. 3Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
  4. 4Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
  1. *Corresponding author. Email: serpersu{at}utk.edu (E.H.S.); cuneomj{at}ornl.gov (M.J.C.)

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