Research ArticleHEALTH AND MEDICINE
A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad
- View ORCID ProfilePrashasti Kumar1,
- View ORCID ProfileEngin H. Serpersu1,2,3,* and
- View ORCID ProfileMatthew J. Cuneo4,*
- 1University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA.
- 2National Science Foundation, 2415 Eisenhower Avenue, Alexandria, VA 22314, USA.
- 3Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
- 4Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
- ↵*Corresponding author. Email: serpersu{at}utk.edu (E.H.S.); cuneomj{at}ornl.gov (M.J.C.)
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Science Advances 04 Apr 2018:
Vol. 4, no. 4, eaas8667
DOI: 10.1126/sciadv.aas8667
Vol. 4, no. 4, eaas8667
DOI: 10.1126/sciadv.aas8667
Prashasti Kumar
1University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA.
Engin H. Serpersu
1University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA.
2National Science Foundation, 2415 Eisenhower Avenue, Alexandria, VA 22314, USA.
3Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
Matthew J. Cuneo
4Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
