Research ArticleDISEASES AND DISORDERS
Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder
- Paul Curtin1,*,†,
- Christine Austin1,*,
- Austen Curtin1,*,
- Chris Gennings1,*,
- Manish Arora1,*,†,
- (for the Emergent Dynamical Systems Group),
- Kristiina Tammimies2,3,
- Charlotte Willfors2,3,
- Steve Berggren2,3,
- Paige Siper4,5,
- Dheeraj Rai6,
- Kristin Meyering4,5,
- Alexander Kolevzon4,5,
- Josephine Mollon7,‡,
- Anthony S. David7,
- Glyn Lewis8,
- Stanley Zammit6,9,
- Lynne Heilbrun10,
- Raymond F. Palmer10,
- Robert O. Wright1,
- Sven Bölte2,3 and
- Abraham Reichenberg1,4,5,7,†
- 1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
- 2Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.
- 3Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.
- 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 5Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 6Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, England.
- 7Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, England.
- 8Division of Psychiatry, Faculty of Brain Sciences, University College London, Maple House, London, England.
- 9Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, Wales.
- 10Family and Community Medicine, School of Medicine, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.
- ↵†Corresponding author. Email: manish.arora{at}mssm.edu (M.A.); paul.curtin{at}mssm.edu (P.C.); avi.reichenberg{at}mssm.edu (A.R.)
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Science Advances 30 May 2018:
Vol. 4, no. 5, eaat1293
DOI: 10.1126/sciadv.aat1293
Vol. 4, no. 5, eaat1293
DOI: 10.1126/sciadv.aat1293
Paul Curtin
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Christine Austin
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Austen Curtin
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Chris Gennings
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Manish Arora
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Kristiina Tammimies
Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.
Charlotte Willfors
Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.
Steve Berggren
Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.
Paige Siper
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dheeraj Rai
Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, England.
Kristin Meyering
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Alexander Kolevzon
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Josephine Mollon
Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, England.
Anthony S. David
Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, England.
Glyn Lewis
Division of Psychiatry, Faculty of Brain Sciences, University College London, Maple House, London, England.
Stanley Zammit
Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, England.Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, Wales.
Lynne Heilbrun
Family and Community Medicine, School of Medicine, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.
Raymond F. Palmer
Family and Community Medicine, School of Medicine, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.
Robert O. Wright
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.
Sven Bölte
Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.
Abraham Reichenberg
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, England.
