Research ArticleCELL BIOLOGY
Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry
- Yuki Hayashi1,2,
- Akiko Fujimura1,*,
- Kazashi Kato1,
- Rina Udagawa1,
- Toru Hirota3 and
- Keiji Kimura1,2,†
- 1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
- 2Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.
- 3Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research, 3-8-1 Ariake, Koto-ku, Tokyo 135-8550, Japan.
- ↵†Corresponding author. Email: kekimura{at}tara.tsukuba.ac.jp
↵* Present address: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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Science Advances 06 Jun 2018:
Vol. 4, no. 6, eaap7777
DOI: 10.1126/sciadv.aap7777
Vol. 4, no. 6, eaap7777
DOI: 10.1126/sciadv.aap7777
Yuki Hayashi
1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
2Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.
Akiko Fujimura
1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
Kazashi Kato
1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
Rina Udagawa
1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
Toru Hirota
3Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research, 3-8-1 Ariake, Koto-ku, Tokyo 135-8550, Japan.
Keiji Kimura
1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba Science City, Ibaraki 305-8577, Japan.
2Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.
