Self-organized stress patterns drive state transitions in actin cortices

Tzer Han Tan; Maya Malik-Garbi; Enas Abu-Shah; Junang Li; Abhinav Sharma; Fred C. MacKintosh; Kinneret Keren; Christoph F. Schmidt; Nikta Fakhri

doi:10.1126/sciadv.aar2847

Research ArticleBIOPHYSICS

Self-organized stress patterns drive state transitions in actin cortices

View ORCID ProfileTzer Han Tan¹,*,
Maya Malik-Garbi²,*,
Enas Abu-Shah²,³,*,
View ORCID ProfileJunang Li¹,
Abhinav Sharma⁴,⁵,†,
View ORCID ProfileFred C. MacKintosh⁴,⁶,⁷,
Kinneret Keren ²,³,⁸,‡,
View ORCID ProfileChristoph F. Schmidt ⁵,⁹,¹⁰,‡ and
View ORCID ProfileNikta Fakhri ¹,‡

¹Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Department of Physics, Technion—Israel Institute of Technology, Haifa, Israel.
³Russell Berrie Nanotechnology Institute, Technion—Israel Institute of Technology, Haifa, Israel.
⁴Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.
⁵Third Institute of Physics—Biophysics, University of Göttingen, Göttingen, Germany.
⁶Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA.
⁷Center for Theoretical Biophysics, Rice University, Houston, TX 77005, USA.
⁸Network Biology Research Laboratories, Technion—Israel Institute of Technology, Haifa, Israel.
⁹German Center for Cardiovascular Research (DZHK), Göttingen, Germany.
¹⁰Department of Physics, Duke University, Durham, NC 27708, USA.

↵‡Corresponding author. Email: kinneret{at}physics.technion.ac.il (K.K.); christoph.schmidt{at}phys.uni-goettingen.de (C.F.S.); fakhri{at}mit.edu (N.F.)

↵* These authors contributed equally to this work.
↵† Present address: Leibniz Institute for Polymer Research, Hohe Strasse 6, 01069 Dresden, Germany.

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Science Advances 06 Jun 2018:
Vol. 4, no. 6, eaar2847
DOI: 10.1126/sciadv.aar2847

Tzer Han Tan

1Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Maya Malik-Garbi

2Department of Physics, Technion—Israel Institute of Technology, Haifa, Israel.

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Enas Abu-Shah

2Department of Physics, Technion—Israel Institute of Technology, Haifa, Israel.

3Russell Berrie Nanotechnology Institute, Technion—Israel Institute of Technology, Haifa, Israel.

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Junang Li

1Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Abhinav Sharma

4Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.

5Third Institute of Physics—Biophysics, University of Göttingen, Göttingen, Germany.

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Fred C. MacKintosh

4Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.

6Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA.

7Center for Theoretical Biophysics, Rice University, Houston, TX 77005, USA.

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ORCID record for Fred C. MacKintosh

Kinneret Keren

2Department of Physics, Technion—Israel Institute of Technology, Haifa, Israel.

3Russell Berrie Nanotechnology Institute, Technion—Israel Institute of Technology, Haifa, Israel.

8Network Biology Research Laboratories, Technion—Israel Institute of Technology, Haifa, Israel.

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For correspondence: kinneret@physics.technion.ac.il christoph.schmidt@phys.uni-goettingen.de fakhri@mit.edu

Christoph F. Schmidt

5Third Institute of Physics—Biophysics, University of Göttingen, Göttingen, Germany.

9German Center for Cardiovascular Research (DZHK), Göttingen, Germany.

10Department of Physics, Duke University, Durham, NC 27708, USA.

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For correspondence: kinneret@physics.technion.ac.il christoph.schmidt@phys.uni-goettingen.de fakhri@mit.edu

Nikta Fakhri

1Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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ORCID record for Nikta Fakhri
For correspondence: kinneret@physics.technion.ac.il christoph.schmidt@phys.uni-goettingen.de fakhri@mit.edu

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