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A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia

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Science Advances  15 Aug 2018:
Vol. 4, no. 8, eaar6637
DOI: 10.1126/sciadv.aar6637

Article Information

vol. 4 no. 8

Online ISSN: 
  • Received for publication December 5, 2017
  • Accepted for publication July 12, 2018
  • .

Author Information

  1. Akiko Sumitomo1,
  2. Kouta Horike1,
  3. Kazuko Hirai1,
  4. Nancy Butcher2,*,
  5. Erik Boot3,
  6. Takeshi Sakurai1,
  7. Frederick C. Nucifora Jr.4,
  8. Anne S. Bassett2,3,5,
  9. Akira Sawa4 and
  10. Toshifumi Tomoda1,5,
  1. 1Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  2. 2Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  3. 3Dalglish Family 22q Clinic, University Health Network, Toronto General Research Institute, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  4. 4Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  5. 5Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
  1. Corresponding author. Email: ttomoda1{at}
  • * Present address: Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.


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