Research ArticleNEUROSCIENCE
A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia
- Akiko Sumitomo1,
- Kouta Horike1,
- Kazuko Hirai1,
- Nancy Butcher2,*,
- Erik Boot3,
- Takeshi Sakurai1,
- Frederick C. Nucifora Jr.4,
- Anne S. Bassett2,3,5,
- Akira Sawa4 and
- Toshifumi Tomoda1,5,†
- 1Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 2Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
- 3Dalglish Family 22q Clinic, University Health Network, Toronto General Research Institute, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
- 4Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
- 5Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
- ↵†Corresponding author. Email: ttomoda1{at}gmail.com
↵* Present address: Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
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Science Advances 15 Aug 2018:
Vol. 4, no. 8, eaar6637
DOI: 10.1126/sciadv.aar6637
Vol. 4, no. 8, eaar6637
DOI: 10.1126/sciadv.aar6637
Akiko Sumitomo
Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kouta Horike
Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kazuko Hirai
Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nancy Butcher
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Erik Boot
Dalglish Family 22q Clinic, University Health Network, Toronto General Research Institute, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Takeshi Sakurai
Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Frederick C. Nucifora
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Anne S. Bassett
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.Dalglish Family 22q Clinic, University Health Network, Toronto General Research Institute, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Akira Sawa
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Toshifumi Tomoda
Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
