Research ArticlePHYSIOLOGY
Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
- Jonathan Cedernaes1,*,
- Milena Schönke2,†,
- Jakub Orzechowski Westholm3,†,
- Jia Mi4,5,
- Alexander Chibalin2,
- Sarah Voisin1,
- Megan Osler2,
- Heike Vogel6,
- Katarina Hörnaeus4,
- Suzanne L. Dickson7,
- Sara Bergström Lind4,
- Jonas Bergquist4,8,9,
- Helgi B Schiöth1,
- Juleen R. Zierath2 and
- Christian Benedict1
- 1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
- 2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
- 3Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
- 4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
- 5Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.
- 6Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
- 7Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- 8Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.
- 9Precision Medicine, Binzhou Medical University, Yantai, China.
- ↵*Corresponding author. Email: jonathan.cedernaes{at}neuro.uu.se
↵† These authors contributed equally to this work.
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Science Advances 22 Aug 2018:
Vol. 4, no. 8, eaar8590
DOI: 10.1126/sciadv.aar8590
Vol. 4, no. 8, eaar8590
DOI: 10.1126/sciadv.aar8590
Jonathan Cedernaes
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Milena Schönke
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Jakub Orzechowski Westholm
Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Jia Mi
Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.
Alexander Chibalin
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Sarah Voisin
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Megan Osler
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Heike Vogel
Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
Katarina Hörnaeus
Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
Suzanne L. Dickson
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sara Bergström Lind
Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
Jonas Bergquist
Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.Precision Medicine, Binzhou Medical University, Yantai, China.
Helgi B Schiöth
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Juleen R. Zierath
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Christian Benedict
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
