Research ArticlePHYSIOLOGY
Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
- View ORCID ProfileJonathan Cedernaes1,*,
- View ORCID ProfileMilena Schönke2,†,
- View ORCID ProfileJakub Orzechowski Westholm3,†,
- Jia Mi4,5,
- Alexander Chibalin2,
- View ORCID ProfileSarah Voisin1,
- Megan Osler2,
- Heike Vogel6,
- Katarina Hörnaeus4,
- Suzanne L. Dickson7,
- View ORCID ProfileSara Bergström Lind4,
- Jonas Bergquist4,8,9,
- Helgi B Schiöth1,
- Juleen R. Zierath2 and
- View ORCID ProfileChristian Benedict1
- 1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
- 2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
- 3Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
- 4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
- 5Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.
- 6Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
- 7Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- 8Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.
- 9Precision Medicine, Binzhou Medical University, Yantai, China.
- ↵*Corresponding author. Email: jonathan.cedernaes{at}neuro.uu.se
↵† These authors contributed equally to this work.
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Science Advances 22 Aug 2018:
Vol. 4, no. 8, eaar8590
DOI: 10.1126/sciadv.aar8590
Vol. 4, no. 8, eaar8590
DOI: 10.1126/sciadv.aar8590
Jonathan Cedernaes
1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Milena Schönke
2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Jakub Orzechowski Westholm
3Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Jia Mi
4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
5Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.
Alexander Chibalin
2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Sarah Voisin
1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Megan Osler
2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Heike Vogel
6Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
Katarina Hörnaeus
4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
Suzanne L. Dickson
7Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sara Bergström Lind
4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
Jonas Bergquist
4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
8Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.
9Precision Medicine, Binzhou Medical University, Yantai, China.
Helgi B Schiöth
1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Juleen R. Zierath
2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Christian Benedict
1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
