Research ArticleIMMUNOLOGY

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection

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Science Advances  08 Aug 2018:
Vol. 4, no. 8, eaas9667
DOI: 10.1126/sciadv.aas9667

Article Information

vol. 4 no. 8

Online ISSN: 
  • Received for publication January 29, 2018
  • Accepted for publication July 1, 2018

Author Information

  1. V. Stalin Raj1,*,,,
  2. Nisreen M. A. Okba1,*,
  3. Javier Gutierrez-Alvarez2,
  4. Dubravka Drabek3,
  5. Brenda van Dieren4,
  6. W. Widagdo1,
  7. Mart M. Lamers1,
  8. Ivy Widjaja4,
  9. Raul Fernandez-Delgado2,
  10. Isabel Sola2,
  11. Albert Bensaid5,
  12. Marion P. Koopmans1,
  13. Joaquim Segalés6,7,
  14. Albert D. M. E. Osterhaus8,9,
  15. Berend Jan Bosch4,
  16. Luis Enjuanes2 and
  17. Bart L. Haagmans1,
  1. 1Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  2. 2Department of Molecular and Cell Biology, National Center for Biotechnology–Spanish National Research Council (CNB-CSIC), Madrid, Spain.
  3. 3Department of Cell Biology, Erasmus Medical Center, Rotterdam, Netherlands.
  4. 4Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  5. 5Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra, Spain.
  6. 6UAB, CReSA (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain.
  7. 7Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Spain.
  8. 8Artemis One Health, Utrecht, Netherlands.
  9. 9Center for Infection Medicine and Zoonoses Research, University of Veterinary Medicine, Hannover, Germany.
  1. Corresponding author. Email: stalin{at} (V.S.R.); b.haagmans{at} (B.L.H.)
    • * These authors contributed equally to this work.

    • Present address: School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM), Kerala, India.


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